http://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/active-researchers-and-publication-links
Active Researchers and Publication Links
Mr Peet Jansen van Rensburg Extraordinary Senior Lecturer Orcid Ms Carien van der Berg Laboratory Technician and Manager Orcid Ms Tarien Jacobs Laboratory Technician Orcid Mr Ruhan van Huyssteen…http://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/funders
Funders
TIA (Technology Innovation Agency; 2011 - 2014) CANSA (Cancer Association of South Africa; 2016-2019) NRF (National Research Foundation; 2022-2024)http://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/history-research-group
History of the Research Group
Based on the high incidence of Chronic Fatigue Syndrome amongst the clinically referred patients, and the role that biotransformation analysis may play to contribute to improved treatment and prognosis of chronic fatigue induced conditions, this TIA / CareDoc / NWU initiative was launched in 2013. Since then, the analysis platforms have…http://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/research-background
Research Background
Monitoring of biotransformation reactions are becoming increasingly relevant as the impact of xenobiotics on the metabolism is beginning to unfold and correlations are found between the production of certain biotransformation products and the development of certain cancers. The complex systems of detoxification enzymes generally function…http://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/research-objectives-and-technologies-used
Research Objectives and Technologies Used
The BOSS research group at the NWU has been involved in the development of a metabolomics approach for the analysis of biotransformation biomarkers. In this approach, targeted analysis of specific biomarkers for biotransformation is used to determine whether abnormalities in these metabolic pathways occur, what the magnitude of these…http://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/current-research-activities-and
Current Research Activities and Developments
Service Delivery: The biotransformation status of clinically referred patients is currently monitored as part of a Biotransformation test package offered by the Centre for Human Metabolomics at the North-West University. The purpose of these tests is to monitor the liver’s reaction to a number of challenge substances. In doing this…http://natural-sciences.nwu.ac.za/biotransformation-and-oxidative-stress-status-laboratory/publications
Publications
C. Petrus, S. Badenhorst, R. Van Der Sluis, Glycine conjugation : importance in metabolism , the role of glycine N -acyltransferase , and factors that influence interindividual variation, (2013) 1–15. C.P.S. Badenhorst, E. Erasmus, R. van der Sluis, C. Nortje, A.A. van Dijk, A new perspective on the importance of…http://natural-sciences.nwu.ac.za/laboratory-infectious-and-acquired-diseases/research-leaders-and-publication-links
Research Leaders and Publication Links
Prof. Du Toit Loots Professor Research: Orcid | Scopus Telephone: +27 18 299 1818 E-mail: dutoit.loots@nwu.ac.za Office: Potchefstroom Campus, Building F3, Room 111 Qualifications: PhD Expertise: Infectious Disease Metabolomics…http://natural-sciences.nwu.ac.za/laboratory-infectious-diseases/contact-us
Contact us
General Contact: Postal Address: Private Bag X 6001 Potchefstroom 2520 South Africa Physical Address: Focus Area for Human Metabolomics Building F3 – Biochemistry …http://natural-sciences.nwu.ac.za/laboratory-infectious-and-acquired-diseases/active-researchers-and-publication-links
Active Researchers and Publication Links
Dr Adetomiwa Adeniji Postdoctoral Fellow Orcid Mr Tumelo Kgoe PhD Student Orcid Mr Simon Isaiah PhD Student Orcid…http://natural-sciences.nwu.ac.za/mitochondrial-laboratory/contact-mitochondrial-research-laboratory
Contact the Mitochondrial Research Laboratory
Postal Address: Private Bag X 6001 Potchefstroom 2520 South Africa Physical Address: Mitochondria Research Laboratory Building F3 – Biochemistry …http://natural-sciences.nwu.ac.za/mitochondria-research-laboratory/active-researchers
Active Researchers
Dr Maryke Schoonen Laboratory Manager Orcid Dr Karin Terburgh Postdoctoral Fellow Orcid Dr Tendai Makwikwi Postdoctoral Fellow Orcid Dr Roksana Majewska PhD Student Orcid…http://natural-sciences.nwu.ac.za/mitochondria-research-laboratory/collaborators
Collaborators
National: Prof Izelle Smuts & Dr Kealeboga Rammego, Department of Paediatrics & Steve Biko Akademic Hospital, University of Pretoria; Prof Jo Wilmshurst, Mrs Surita Meldau, Dr Gill Riordan, Department of Paediatric Neurology, Red Cross War Memorial Children’s Hospital, and NHLS Laboratory at the University of Cape Town…http://natural-sciences.nwu.ac.za/mitochondria-research-laboratory/history-research-group
History of the Research Group
The group was formed in 2001 with the aim of forming a specialist research group to study and provide biochemical diagnostic capacity for mitochondrial- and other inherited metabolic diseases in South Africa. Over two decades this research aim expanded in scope to now include a wide range of investigations in several types of disease…http://natural-sciences.nwu.ac.za/mitochondria-research-laboratory/background-research
Background to the Research
With the background and expertise of the division of Biochemistry in inherited metabolic diseases and metabolism, the research topics of the group are structured around the involvement of the mitochondrial oxidative phosphorylation (OXPHOS) system in human diseases. Defects in the mitochondrial energy metabolism is not only the largest group of…http://natural-sciences.nwu.ac.za/mitochondrial-laboratory/research-objectives-and-technologies-used
Research Objectives and Technologies Used
The MRL is set up to investigate various aspects of mitochondrial function and disease from different approaches and is therefore a truly multidisciplinary research group. The laboratory is a very well-equipped with specialised apparatus for the following: Mitochondrial function: Mitochondrial…http://natural-sciences.nwu.ac.za/mitochondrial-laboratory/current-research-activities-and-developments
Current Research Activities and Developments
The current projects of the MRL fall into three groups: Mitochondrial disorders in the SA population: molecular genetics and metabolomics Cohort investigations with national and international researchers and clinicians Adaptive responses in…http://natural-sciences.nwu.ac.za/mitochondrial-laboratory/publications
Publications
Our publications are listed in order of the most relevant over the last five years: Reinecke CJ, Koekemoer G, van der Westhuizen FH, Louw R, Lindeque JZ, Mienie LJ, Smuts I. 2012. Metabolomics of urinary organic acids in respiratory chain deficiencies. Metabolomics 8, 264-283 (IF 4.505). van der Walt EM…http://natural-sciences.nwu.ac.za/natural-sciences/nwu-research-awards-2017